AnalyzeDirect Johnstrom P, Fryer TD, Richards HK, Harris NG, Barret O, Clark JC, Pickard JD, Davenport AP. Positron emission tomography using 18F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ETB receptors in vivo. Br J Pharmacol. January 2005;144(1):115-122.
Full Text – Open Access
Publication Date
January 2005
How Analyze was Used
“Regions-of-interest (ROI) were delineated for the organs of interest using Analyze (Robb et al., 1989) (AnalyzeDirect Inc., Lenexa, USA) to construct time–activity curves.”
Keywords
Animals
Endothelin-1/metabolism
Fluorine Radioisotopes/pharmacokinetics
Heart Ventricles/metabolism/radionuclide imaging
Humans
Male
Positron-Emission Tomography (PET)/methods
Rats
Rats, Sprague-Dawley
Receptors, Endothelin/metabolism
Tissue Distribution
Author Affiliation(s)
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (PJ, APD)
Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (TDF, NGH, OB, JCC, JDP)
Academic Neurosurgery Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (HKR, NGH, JDP)
ID# 2092
Tags: Animals, Endothelin Receptors/metabolism, Endothelin-1/metabolism, Fluorine Radioisotopes/pharmacokinetics, Heart Ventricles/metabolism/radionuclide imaging, Humans, Male, Positron-Emission Tomography (PET)/methods, Rats, Sprague-Dawley Rats, Tissue Distribution