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Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms

Uchida H, Kapur S, Mulsant BH, Graff-Guerrero A, Pollock BG, Mamo DC. Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. Am J Geriatr Psychiatry. March 2009;17(3):255-263.

Publication Date
March 2009

How Analyze was Used
“ROI analysis was completed by one of the investigators (HU) using Analyze software Version 6.0 (AnalyzeDirect, Lenexa, KS).”

Keywords
Aged
Aged, 80 and over
Antipsychotic Agents/adverse effects/pharmacokinetics
Basal Ganglia Diseases/chemically induced
Case-Control Studies
Cross-Sectional Studies
Dopamine Antagonists/blood
Female
Humans
Isoxazoles/blood
Male
Middle Aged
Ontario/epidemiology
Positron-Emission Tomography (PET)
Psychiatric Status Rating Scales
Psychotic Disorders/drug therapy/metabolism/radionuclide imaging
Pyrimidines/blood
Raclopride/metabolism/pharmacology
Receptors, Dopamine D2/drug effects/metabolism
Risperidone/adverse effects/pharmacokinetics
Schizophrenia/drug therapy/metabolism/radionuclide imaging
Treatment Outcome

Author Affiliation(s)
PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada. (HU, SK, AGG, DCM)

Department of Psychiatry, University of Toronto, ON, Canada. (HU, SK, BHM, BGP, DCM)

Institute of Psychiatry, King’s College, London, UK. (SK)

Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, ON, Canada. (BHM, BGP, DCM)

Institute of Neurobiology, Universidad Nacional Autonoma de Mexico; The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada. (AGG, BGP)

ID# 1289

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