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Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation

Garvey LJ, Pavese N, Ramlackhansingh A, Thomson E, Allsop JM, Politis M, Kulasegaram R, Main J, Brooks DJ, Taylor-Robinson SD, Winston A. Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. PLoS One. July 2012;7(7):e38980.

Full Text – Open Access

Publication Date
July 2012

How Analyze was Used
“For each patient, PK11195 BP [binding potential] values in the parietal, occipital, frontal, temporal, ventral striatum, caudate, putamen and thalamus regions were calculated by applying standardised object maps to normalized 11C-[R]-PK11195 BP images in Analyze software (Analyze AVW).”

Keywords
Acute Disease
Adult
Biological Transport
Carbon Radioisotopes
Case-Control Studies
Cerebral Cortex/metabolism/physiopathology/virology
Chronic Disease
Cognition
Coinfection
HIV/physiology
HIV Infections/metabolism/physiopathology/virology
Hepacivirus/physiology
Hepatitis C/metabolism/physiopathology/virology
Humans
Isoquinolines/metabolism
Magnetic Resonance Spectroscopy
Male
Microglia/metabolism/virology
Middle Aged
Neuropsychological Tests
Positron-Emission Tomography (PET)
RNA, Viral/metabolism

Author Affiliation(s)
Department of Medicine, Imperial College London, London, UK. (LJG, ET, JM, SDT-R, AW)

Department of HIV and GU Medicine, Imperial College Healthcare NHS Trust, London,  UK. (LJG, ET, JW, AW)

Neurosciences Section, Division of Experimental Medicine, Imperial College London, London,  UK. (NP, AR, MP, DJB)

Imaging Sciences Department, Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, London,  UK. (JMA)

Department of HIV and GU Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, UK. (RK)

ID# 947

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