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Changani K, Hotee S, Campbell S, Pindoria K, Dinnewell L, Saklatvala P, Thompson SA, Coe D, Biggadike K, Vitulli G, Lines M, Busza A, Denyer J. Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig. Br J Pharmacol. June 2013;169(3):580-589.

Full Text – Open Access

Publication Date
June 2013

How Analyze was Used
“Nasal airspace and fluid volumes were quantified using Analyze 7.0 software.”

Keywords
Atropine
Capsaicin
Guinea Pig
Hypertonic Saline
Magnetic Resonance Imaging (MRI)
Nasal Sensory Nerves
Parasympathetic Reflex
SB-705498
TRPV1 Ion Channel

Author Affiliation(s)
Respiratory Therapeutic Area, GlaxoSmithKline, Stevenage, UK. (SH, LD, PS, SAT, DC, KB, GV, AB, JD)

Platform Technology and Science, GlaxoSmithKline, Stevenage, UK. (KC, SC, KP, ML)

ID# 411

Tags: Atropine, Capsaicin, Guinea Pig, Hypertonic Saline, Magnetic Resonance Imaging (MRI), Nasal Sensory Nerves, Parasympathetic Reflex, SB-705498, TRPV1 Ion Channel