AnalyzeDirect Alisa E Lee et al. A cross‐sectional cohort study of the effects of FGF23 deficiency and hyperphosphatemia on dental structures in hyperphosphatemic familial tumoral calcinosis JBMR Plus.
Publication Date
February 2, 2021
How Analyze was Used
“Teeth samples were analyzed using a micro-CT 50 scanner (Scanco Medical, Bassersdorf, Switzerland) at 70 kVp, 76 µA, 0.5 Al filter, 900 ms integration, and 10 µm voxel size. AnalyzePro 1.0 (AnalyzeDirect, Overland Park, KS, USA) was used to reconstruct and analyze images. Images were anatomically oriented and calibrated to a linear standard curve created using hydroxyapatite phantoms with known densities. Enamel was segmented ≥ 1650 mg HA/cm3, and dentin/cementum at 600–1649 mg HA/cm3. HFTC dentin and cementum were indistinguishable by density, so dentin and cementum were combined for analysis. Pulp was segmented using a combination of manual and semi-automatic functions. Heat maps were generated for density visualization.”
Keywords
Dental biology, Bone QCT/μCT, Molecular pathways ‐ development, PTH/Vit D/FGF23, Disorders of calcium/phosphate metabolism
Author Affiliation(s)
National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, Maryland, USA
