AnalyzeDirect

Alfonso Eirin¹, Behzad Ebrahimi¹, Soon Hyo Kwon¹, Justin A. Fiala¹, Barbara J. Williams¹, John R. Woollard¹, Quan He², Ramech C. Gupta³, Hani N. Sabbah³, Y.S. Prakash⁴, Stephen C. Textor¹, Amir Lerman⁵, Lilach O. Lerman^1,5. Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension. Journal of the American Heart Association. 31 May 2016.

Full Text – Open Access

Publication Date
May 2016

How Analyze was Used
“The entire LV was scanned throughout the cardiac cycle to obtain cardiac systolic function, end‐diastolic volume (EDV), and LV muscle mass (LVMM). Early (E) and late (A) LV filling rates were obtained from the volume/time curve, and myocardial perfusion from time‐attenuation curves obtained from the anterior cardiac wall, as described. Images were analyzed with the Analyze software package (Biomedical Imaging Resource; Mayo Clinic, Rochester, MN). […] An LV transmural portion (2 cm3) was scanned, and images analyzed, as described. The spatial density and average diameter of microvessels in the subepicardium and subendocardium were calculated using Analyze, and vessel tortuosity (maturity index) calculated.”

Keywords
bendavia
heart failure
hypertension
mitochondria
renal artery stenosis
renovascular hypertension

Author Affiliation(s)
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
²Diabetes and Obesity Research Center, Sanford‐Burnham Medical Research Institute, Orlando, FL
³Division of Cardiovascular Medicine, Henry Ford Health System, Detroit, MI
⁴Department of Anesthesiology, Mayo Clinic, Rochester, MN
⁵Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN

Tags: Heart Failure, Heart Mitochondria/metabolism, Hypertension, Renal Artery Stenosis, Renovascular Hypertension