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[11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?

Hammers A, Panagoda P, Heckemann RA, Kelsch W, Turkheimer FE, Brooks DJ, Duncan JS, Koepp MJ. [11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling? J Cereb Blood Flow Metab. January 2008;28(1):207-216.

Full Text – Open Access

Publication Date
January 2008

How Analyze was Used
“The input kinetics were derived from the pons. This was defined by spatial warping of a version of our frequency-based human brain atlas (Hammers et al, 2003a) onto each subject’s MRI using SPM software … (Ashburner and Friston 2005), subsequent coregistration of MRI and transformed atlas onto a weighted 90 mins summed activity image of that subject, and sampling of the radioactivity concentration in all time frames of the dynamic data using Analyze AVW 7.0.”

Keywords
Adult
Carbon Isotopes/administration & dosage
Cerebrovascular Circulation
Epilepsy, Temporal Lobe/diagnosis/pathology/physiopathology/radionuclide
imaging
Female
Flumazenil/administration & dosage
GABA Modulators/administration & dosage
Hippocampus/pathology/physiopathology/radionuclide imaging
Humans
Kinetics
Male
Middle Aged
Models, Biological
Positron-Emission Tomography (PET)
Predictive Value of Tests
Sclerosis

Author Affiliation(s)
MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK. (AH, PP, RAH, FET, DJB, MJK)

Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK. (AH, WK, JSD, MJK)

National Society for Epilepsy MRI Unit, Chalfont St Peter, UK. (AH, WK, JSD, MJK)

ID# 1612

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