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SISCOM (Subtraction Ictal SPECT CO-registered to MRI) is a powerful research application that uses a combination of SPECT and MRI to assess regional activation in the brain. The technique takes advantage of the transient focal increase in cerebral blood flow that occurs during certain types of neurological events. SPECT imaging techniques have demonstrated the potential to map blood flow patterns during resting and event states, but with poor spatial resolution. When co-registered (fused) with an MRI, SISCOM provides fusion of the critical functional information from the SPECT scans with the structural detail of the MRI, an important synergistic visualization which allows direct functional to structural correlation and analysis.