AnalyzeDirect

Xuyi Yue¹, Hongjun Jin¹, Zonghua Luo¹, Hui Liu¹, Xiang Zhang¹, Ethan D. McSpadden², Linlin Tian³, Hubert P. Flores³, Joel S. Perlmutter^1,3, Stanley M. Parsons², Zhude Tu¹. Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (-)-[18F]TZ3108 in rodent and the nonhuman primate brain. Bioorganic & Medicinal Chemistry. January 16 2017.

Publication Date
January 2017

How Analyze was Used
“The MRI (MPRAGE) was co-registered to the baseline PET image. All volume of interest (VOI) were drawn on the MPRAGE image using Vidi or Analyze program (AnalyzeDirect Inc., Overland Park, KS). Three-dimensional VOIs were transformed to the PET space and then overlaid on all reconstructed PET images to obtain TACs.”

Keywords
Fluorine-18, Enantiomer, σ1 receptor, PET imaging

Author Affiliation(s)
¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
²Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA
³Department of Neurology, Washington University School of Medicine, St Louis, MO, USA

Tags: Enantiomer, Fluorine-18, PET imaging, σ1 receptor